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RSS feedDisplaying articles 31 - 40 of most recent articles

[Report] The phenotypic legacy of admixture between modern humans and Neandertals Many modern human genomes retain DNA inherited from interbreeding with archaic hominins, such as Neandertals, yet the influence of this admixture on human traits is largely unknown. We analyzed the contribution of common Neandertal variants to over 1000 e
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[Report] Spatial colocalization and functional link of purinosomes with mitochondria Purine biosynthetic enzymes organize into dynamic cellular bodies called purinosomes. Little is known about the spatiotemporal control of these structures. Using super-resolution microscopy, we demonstrated that purinosomes colocalized with mitochondria,
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[Report] mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle In response to growth signals, mechanistic target of rapamycin complex 1 (mTORC1) stimulates anabolic processes underlying cell growth. We found that mTORC1 increases metabolic flux through the de novo purine synthesis pathway in various mouse and human c
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[Report] Structural basis for histone H2B deubiquitination by the SAGA DUB module Monoubiquitinated histone H2B plays multiple roles in transcription activation. H2B is deubiquitinated by the Spt-Ada-Gcn5 acetyltransferase (SAGA) coactivator, which contains a four-protein subcomplex known as the deubiquitinating (DUB) module. The cryst
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[Report] Dynamics of epigenetic regulation at the single-cell level Chromatin regulators play a major role in establishing and maintaining gene expression states. Yet how they control gene expression in single cells, quantitatively and over time, remains unclear. We used time-lapse microscopy to analyze the dynamic effect
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[Report] Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E Major histocompatibility complex E (MHC-E) is a highly conserved, ubiquitously expressed, nonclassical MHC class Ib molecule with limited polymorphism that is primarily involved in the regulation of natural killer (NK) cells. We found that vaccinating rhe
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[Report] Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion T cellmediated destruction of insulin-producing cells in the pancreas causes type 1 diabetes (T1D). CD4 T cell responses play a central role in cell destruction, but the identity of the epitopes recognized by pathogenic CD4 T cells remains unknown. We fou
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[Report] Pulmonary neuroendocrine cells function as airway sensors to control lung immune response The lung is constantly exposed to environmental atmospheric cues. How it senses and responds to these cues is poorly defined. Here, we show that Roundabout receptor (Robo) genes are expressed in pulmonary neuroendocrine cells (PNECs), a rare, innervated e
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[Report] Artificial electron acceptors decouple archaeal methane oxidation from sulfate reduction The oxidation of methane with sulfate is an important microbial metabolism in the global carbon cycle. In marine methane seeps, this process is mediated by consortia of anaerobic methanotrophic archaea (ANME) that live in syntrophy with sulfate-reducing b
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[Report] A decade of sea level rise slowed by climate-driven hydrology Climate-driven changes in land water storage and their contributions to sea level rise have been absent from Intergovernmental Panel on Climate Change sea level budgets owing to observational challenges. Recent advances in satellite measurement of time-va
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