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Articles from ScienceNOW

RSS feedDisplaying articles 1 - 10 of most recent articles

[Report] Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain The human brain has enormously complex cellular diversity and connectivities fundamental to our neural functions, yet difficulties in interrogating individual neurons has impeded understanding of the underlying transcriptional landscape. We developed a sc
ScienceNOW | Jun 23, 2016 8:29 PM [GMT] | comment? | recommend
[Report] Synthetic evolutionary origin of a proofreading reverse transcriptase Most reverse transcriptase (RT) enzymes belong to a single protein family of ancient evolutionary origin. These polymerases are inherently error prone, owing to their lack of a proofreading (3- 5 exonuclease) domain. To determine if the lack of proofreadi
ScienceNOW | Jun 23, 2016 8:29 PM [GMT] | comment? | recommend
[New Products] New Products A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
ScienceNOW | Jun 23, 2016 8:29 PM [GMT] | comment? | recommend
[Working Life] A winding path to satisfaction Author: Sarah Fankhauser
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[Research Article] Designer nanoscale DNA assemblies programmed from the top down Scaffolded DNA origami is a versatile means of synthesizing complex molecular architectures. However, the approach is limited by the need to forward-design specific Watson-Crick base pairing manually for any given target structure. Here, we report a gener
ScienceNOW | Jun 23, 2016 8:29 PM [GMT] | comment? | recommend
[Research Article] A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion Innate immune signaling pathways contribute to the protection of host tissue when bacterially challenged. Colonic goblet cells are responsible for generating the two mucus layers that physically separate the luminal microbiota from the host epithelium. An
ScienceNOW | Jun 23, 2016 8:29 PM [GMT] | comment? | recommend
[Research Article] Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase The Hsp90 molecular chaperone and its Cdc37 cochaperone help stabilize and activate more than half of the human kinome. However, both the mechanism by which these chaperones assist their client kinases and the reason why some kinases are addicted to Hsp90
ScienceNOW | Jun 23, 2016 8:29 PM [GMT] | comment? | recommend
[Research Article] Exploring the many-body localization transition in two dimensions A fundamental assumption in statistical physics is that generic closed quantum many-body systems thermalize under their own dynamics. Recently, the emergence of many-body localized systems has questioned this concept and challenged our understanding of th
ScienceNOW | Jun 23, 2016 8:29 PM [GMT] | comment? | recommend
[Report] Quantum phase magnification Quantum metrology exploits entangled states of particles to improve sensing precision beyond the limit achievable with uncorrelated particles. All previous methods required detection noise levels below this standard quantum limit to realize the benefits o
ScienceNOW | Jun 23, 2016 8:29 PM [GMT] | comment? | recommend
[Report] Allosteric initiation and regulation of catalysis with a molecular knot Molecular knots occur in DNA, proteins, and other macromolecules. However, the benefits that can potentially arise from tying molecules in knots are, for the most part, unclear. Here, we report on a synthetic molecular pentafoil knot that allosterically i
ScienceNOW | Jun 23, 2016 8:29 PM [GMT] | comment? | recommend