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Articles from ScienceNOW

RSS feedDisplaying articles 1 - 10 of most recent articles

[Research Article] Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability Temperature-induced cell death is thought to be due to protein denaturation, but the determinants of thermal sensitivity of proteomes remain largely uncharacterized. We developed a structural proteomic strategy to measure protein thermostability on a prot
ScienceNOW | Feb 23, 2017 9:28 PM [GMT] | comment? | recommend
[Research Article] The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport DNA charge transport chemistry offers a means of long-range, rapid redox signaling. We demonstrate that the [4Fe4S] cluster in human DNA primase can make use of this chemistry to coordinate the first steps of DNA synthesis. Using DNA electrochemistry, we
ScienceNOW | Feb 23, 2017 9:28 PM [GMT] | comment? | recommend
[Review] Mechanisms for initiating cellular DNA replication Cellular DNA replication factories depend on ring-shaped hexameric helicases to aid DNA synthesis by processively unzipping the parental DNA helix. Replicative helicases are loaded onto DNA by dedicated initiator, loader, and accessory proteins during the
ScienceNOW | Feb 23, 2017 9:28 PM [GMT] | comment? | recommend
[Editorial] Approving new drugs As the Trump administration takes shape, there is much speculation as to what major changes will be made. A dominant theme of the Trump campaign was to cut through bureaucracy in Washington, D.C., thereby enhancing innovation and bringing new technology t
ScienceNOW | Feb 23, 2017 9:28 PM [GMT] | comment? | recommend
[In Brief] News at a glance In science news around the world, China sees a spike in cases of H7N9 infection, India plans a follow-up Mars mission and considers a mission to Venus, the U.S. Department of Agriculture restores some of the tens of thousands of animal welfare documents s
ScienceNOW | Feb 23, 2017 9:28 PM [GMT] | comment? | recommend
[In Depth] California rains put spotlight on atmospheric rivers In just a few months, California has moved from extreme drought to dangerous flooding, thanks to atmospheric rivers: long, narrow ribbons of water vapor in the sky. Just a few hundred kilometers wide, atmospheric rivers stretch thousands of kilometers fro
ScienceNOW | Feb 23, 2017 9:28 PM [GMT] | comment? | recommend
[Perspective] A Mesozoic aviary The evolution of birds from a group of small dinosaurs between 170 million and 150 million years ago has emerged as a textbook example of a major evolutionary transformation in the fossil record (1). The attainment of powered flightthat is, active flappin
ScienceNOW | Feb 23, 2017 9:28 PM [GMT] | comment? | recommend
[Perspective] Quantifying protein (dis)order Twenty-five years ago, Chothia predicted that the structural domains of all proteins can be classified into about 1000 folds (1). Later studies refined this number; however, scientists also found that some proteins or parts of proteins never assume a spec
ScienceNOW | Feb 23, 2017 9:28 PM [GMT] | comment? | recommend
[Perspective] Why tolerance invites resistance Bacteria use two strategies to avoid being killed by antibiotics: resistance and tolerance. Resistance mechanisms such as destruction of a drug or modification of its target allow bacteria to grow in the presence of antibiotics. Tolerance is a property of
ScienceNOW | Feb 23, 2017 9:28 PM [GMT] | comment? | recommend
[Perspective] Molecular stitches for enhanced recycling of packaging Polymers made of even slightly different repeat units are usually immiscible and form materials with two separate phases, like oil and water. Not only do different polymers not mix, but the interfaces between them are very sharp and mechanically weak. Thi
ScienceNOW | Feb 23, 2017 9:28 PM [GMT] | comment? | recommend